Easiest way to give up smoking - ZYBAN.

Zyban is a prescription medicine to help people quit smoking. Studies have shown that more than one third of people quit smoking for at least 1 month while taking Zyban and participating in a patient support program. For many patients, Zyban reduces withdrawal symptoms and the urge to smoke. Zyban should be used with a patient support program. It is important to participate in the behavioral program, counseling, or other support program your healthcare professional recommends.

Who should not take Zyban?

Do not take Zyban if you:
have or had a seizure disorder or epilepsy.
are taking WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, or any other medicines that contain bupropion hydrochloride. Bupropion is the same active ingredient that is in Zyban.
drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy) or benzodiazepines and you stop using them all of a sudden.


have taken within the last 14 days medicine for depression called a monoamine oxidase inhibitor (MAOI), such as NARDIL®*(phenelzine sulfate), PARNATE®(tranylcypromine sulfate), or MARPLAN®*(isocarboxazid).
have or had an eating disorder such as anorexia nervosa or bulimia.
are allergic to the active ingredient in Zyban, bupropion, or to any of the inactive ingredients. See the end of this leaflet for a complete list of ingredients in Zyban.

What should I tell my doctor before using Zyban?

Tell your doctor if you have ever had depression, suicidal thoughts or actions, or other mental health problems. You should also tell your doctor about any symptoms you had during other times you tried to quit smoking, with or without Zyban. See “Quitting Smoking, Quit-Smoking Medications, Changes in Thinking and Behavior, Depression, and Suicidal Thoughts or Actions.”

Tell your doctor about your other medical conditions, including if you
are pregnant or plan to become pregnant. It is not known if Zyban can harm your unborn baby.
are breastfeeding. Zyban passes through your milk. It is not known if Zyban can harm your baby.
have liver problems, especially cirrhosis of the liver.
have kidney problems.
have an eating disorder such as anorexia nervosa or bulimia.
have had a head injury.
have had a seizure (convulsion, fit).
have a tumor in your nervous system (brain or spine).
have had a heart attack, heart problems, or high blood pressure.
are a diabetic taking insulin or other medicines to control your blood sugar.
drink a lot of alcohol.
abuse prescription medicines or street drugs.
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Many medicines increase your chances of getting seizures or other serious side effects if you take them while you are using Zyban.

How should I take Zyban?
Take Zyban exactly as prescribed by your doctor.
Do not chew, cut, or crush Zyban Tablets. You must swallow the tablets whole. Tell your doctor if you cannot swallow medicine tablets.
Take Zyban at the same time each day.
Take your doses of Zyban at least 8 hours apart.
If you miss a dose, do not take an extra tablet to make up for the dose you forgot. Wait and take your next tablet at the regular time. This is very important. Too much Zyban can increase your chance of having a seizure.
If you take too much Zyban, or overdose, call your local emergency room or poison control center right away.
Do not take any other medicines while using Zyban unless your doctor has told you it is okay.
Do not change your dose or stop taking Zyban without talking with your doctor first.

How long should I take Zyban?

Most people should take Zyban for at least 7 to 12 weeks. Some people may need to take Zyban for a longer period of time to assist in their smoking cessation efforts. Follow your doctor’s instructions.

When should I stop smoking?

It takes about 1 week for Zyban to start working. For your best chance of quitting, you should not stop smoking until you have been taking Zyban for 1 week. You should set a date to stop smoking during the second week you're taking Zyban.

Can I smoke while taking Zyban?

It is not physically dangerous to smoke and use Zyban at the same time. But you will seriously lower your chance of breaking your smoking habit if you smoke after the date you set to stop smoking.

Can Zyban be used at the same time as nicotine patches?

Yes, Zyban and nicotine patches can be used at the same time but should only be used together under the supervision of your doctor. Using Zyban and nicotine patches together may raise your blood pressure, sometimes severely. Tell your doctor if you are planning to use nicotine replacement therapy because your doctor should check your blood pressure regularly.

Do not smoke at any time if you are using a nicotine patch or any other nicotine product along with Zyban. It is possible to get too much nicotine and have serious side effects.

What should I avoid while taking Zyban?
Do not drink a lot of alcohol while taking Zyban. If you usually drink a lot of alcohol, talk with your doctor before suddenly stopping. If you suddenly stop drinking alcohol, you may increase your chance of having seizures.
Do not drive a car or use heavy machinery until you know how Zyban affects you. Zyban can affect your ability to do these things safely.

What are possible side effects of Zyban?

Zyban can cause serious side effects. Read this entire Medication Guide for more information about these serious side effects.

The most common side effects of Zyban are dry mouth and trouble sleeping. These side effects are generally mild and often disappear after a few weeks. If you have trouble sleeping, do not take Zyban too close to bedtime.

These are not all the side effects of Zyban. For a complete list, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store Zyban?
Store Zyban at room temperature. Store out of direct sunlight. Keep Zyban in its tightly closed bottle.
Zyban may have an odor.

General Information about Zyban.
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Zyban for a condition for which it was not prescribed. Do not give Zyban to other people, even if they have the same symptoms you have. It may harm them. Keep Zyban out of the reach of children.

This Medication Guide summarizes important information about Zyban. For more information, talk with your doctor. You can ask your doctor or pharmacist for information about Zyban that is written for health professionals.

What are the ingredients in Zyban?

Active ingredient: bupropion hydrochloride.

Inactive ingredients: carnauba wax, cysteine hydrochloride, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80 and titanium dioxide. The tablets are printed with edible black ink. In addition, the 150-mg tablet contains FD&C Blue No. 2 Lake and FD&C Red No. 40 Lake.

WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, and PARNATE are registered trademarks of GlaxoSmithKline.

*The following are registered trademarks of their respective manufacturers: NARDIL®/Warner Lambert Company; MARPLAN®/Oxford Pharmaceutical Services.

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